Publications

Peer-Reviewed Publications

2026

  • Ryan G. Toedebusch, Chang-il Hwang, Shafee Syed-Quadri, Orwa Aboud, Kevin D. Woodlard, Daniel York, Maciej Parys, Peter J. Dickinson, Frederick J. Meyers, John D. McPherson, and Christine M. Toedebusch. Heterogeneous DNA methylation and gene expression patterns underly metabolic plasticity in canine astrocytoma-derived stem-like cells. Front Oncol. IN PRESS.
  • AM Dupanloup, PJ Dickinson, CM Toedebusch, CM Unkel, WTN Culp, MF Knipe. Perioperative Assessment of Electroencephalography in Dogs with Congenital Portosystemic Shunts. JVIM. IN PRESS.
  • Jaime L. Peyton,  William T. Culp, Rich Larson, S. Jason Peters, Christine M. Toedebusch, and Eric G. Johnson. Front. Vet. Sci. 2026.

 

2024

  • Panek WK, Toedebusch RG, Mclaughlin BE, Dickinson PJ, Van Dyke JE, Woolard KD, Berens ME, Lesniak MS, Vernau KM, Li C-F, Miska J, Toedebusch CM. The CCL2-CCR4 axis promotes regulatory T cell trafficking to canine glioma tissues. J Neurooncol. PMID 39046599.
  • Zakimi N, Mazcko CN, Toedebusch CM, Tawa G, Woolard K, LeBlanc AK, Dickinson PJ, Raleigh DR. Canine meningiomas are comprised of 3 DNA methylation groups that resemble the molecular characteristics of human meningiomas. Acta Neuropath, 2024. PMID 38376604.
  • Choudhury A, Cady MA,, Lucas CHG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Ochoa-Birrueta J, Chen WC, Oberheim Bush NA, Hervey-Jumper SL, Klein O, Toedebusch CM, Horbinski CM, Magill ST, Bhaduri A, Perry A, Dickinson PJ, Heimberger AB, Ashworth A, Crouch EA and Raleigh DR. Perivascular NOTCH3+ stem cells drive meningioma tumorigenesis and resistance to radiotherapy. Cancer Discov, 2024. PMID 38742767.
  • Razmara AM, Gingrich AA, Toedebusch CM, Rebhun RB, Murphy WJ, Kent MS, and Canter RJ. Improved characterization and translation of NK cells for canine immunotherapy. Front Vet Sci. 2024. PMID 38379924.

 

2023

  • Mathews K, Toedebusch CM, Palm C, Kendall A, Westropp JL. Canine Idiopathic Functional Urinary Outflow Tract Obstruction, a retrospective case series (2010-2021): 31 cases. JVIM. 2023. PMID 37775972.
  • Toedebusch RG, Wei NW, Simafranca KT, Furth-Jacobus JA, Brust-Mascher I, Stewart S, Dickinson PJ, Woolard, K, Li, CF, Vernau, K, Meyers FJ, and Toedebusch, CM. Intra- and intertumoral microglia/macrophage infiltration and their associated molecular signature is highly variable in canine oligodendroglioma. Vet Sci. 2023. PMID 37368789.

 

2022

  • Joseph LM, Debebe E, Bastian AH, Toedebusch RG, Lucchesi CA, Wittenburg LA, Chen X, Meyers FJ and Toedebusch CM. Olfactomedin-like 3 promotes primary mouse brain endothelial cell proliferation, migration, and differentiation. Int. J. Mol. Sci. 2022. PMID 36498941.
  • Kent MS, Karchemskiy S, Culp WTN, Lejeune AT, Pesavento, Toedebusch CM, Brady R, and Rebhun R.  Longevity and mortality in cats: A single institution necropsy study of 3108 cases (1989-2019). PLoS One. 2022. PMID 36580443.
  • Razmara AM, Wittenburg LA, Al-Nadaf S, Toedebusch RG, Meyers FJ, Toedebusch CM. Prevalence and Clinicopathologic Features of Canine Metastatic Melanoma involving the Central Nervous System: A retrospective analysis and comparative review.     Front. Oncol. 2022. PMID 35692802.

 

2021

  • Toedebusch RG, Lucchesi CA, Debebe ET, Wittenburg LA, Chen X, and Toedebusch CM. Microglia-derived olfactomedin-like 3 Promotes Pro-tumorigenic Microglial Function and Glioma Cell Malignancy. Int. J. Mol. Sci. 2021. PMID 34884869.
  • Murthy VM, Li CF, Hicks J, Kroll, J, Giuffrida M, Dickinson PJ, and Toedebusch CM. Serum phosphorylated neurofilament heavy chain as a diagnostic biomarker for progressive myelomalacia in dogs with thoracolumbar intervertebral disc herniation. J Vet Intern Med. 2021. PMID 34476832.
  • Toedebusch, RG, Grodzki, AC, Dickinson, PJ, Woolard, K, Vinson, NM, Nicole Vinson, Sturges, B, Snyder, J, Li, CF, Nagasaki, OM, Consales, BM, Vernau, K, Knipe, M, Murthy, V, Lein, PJ, and Toedebusch, CM. Glioma-associated microglia/macrophages augment tumorigenicity in canine astrocytoma, a naturally occurring model of human glioma. NeuroOncology Advances. 2021. PMID 34131649.

 

2020 and earlier:

  • Toedebusch, CM, Garcia VB Snyder JC, Jones MR, Schulz DJ, Johnson GC, Villalon EL, Coates JR and Garcia ML. Lumbar spinal cord microglia exhibited increased activation in aged dogs compared to young adult dogs. Geroscience. 2020. PMID 31828496.
  • Toedebusch, CM, Snyder JC, Jones MR, Garcia VB, Johnson GC, Villalon EL, Coates JR and Garcia ML. Arginase-1 expressing microglia in close proximity to motor neurons were increased early in disease progression in canine degenerative myelopathy, a model of amyotrophic lateral sclerosis. Mol Cell Neurosci. 2018. PMID 29408267.
  • Toedebusch, CM, Bachrach MF, Garcia VB, Johnson GC, Katz ML, Shaw G, Coates JR, and Garcia ML. Cerebrospinal fluid levels of phosphorylated neurofilament heavy (pNF-H) as a diagnostic marker of canine degenerative myelopathy. J Vet Intern Med. 2017. PMID 28186658
  • Villalon E., Jones MR, Sibigtroth C, Zino SJ, Dale JM, Landayan DS, Shen H, Cornelison DDW, and Garcia ML. Muscle spindle alterations precede onset of sensorimotor deficits in Charcot-Marie-Tooth type 2E. Genes, Brain, Behav. 2017. PMID 27643807.
  • Shababi M, Feng Z, Villalon E, Sibigtroth CM, Osman EY, Miller MR, Williams-Simon PA, Lombardi A, Sass TH, Atkinson AK, Garcia ML, Ko CK and Lorson CL. Rescue of a mouse model of spinal muscular atrophy with respiratory distress type 1 by AAV9- IGHMBP2 is dose dependent. Mol Ther. 2016. PMID  26860981.
  • Katz ML, Coates JR, Sibigtroth CM, Taylor JC, Carpentier M, Young WM, Wininger FA , Kennedy D, Vuillemenot BR and O’Neill CA. Enzyme replacement therapy attenuates disease progression in a canine model of late-infantile neuronal ceroid lipofuscinosis (CLN2 disease). J.Neuorsci. Res. 2014. PMID 24938720.
  • Smith SMC, Mitchell GS, Friedle SA, Sibigtroth CM, Vinit, S, Watters JJ. Hypoxia attenuates purinergic P2X receptor induced inflammatory gene expression in brainstem microglia. HypoxicSignaling. 2013. PMID 24377098.

  • Sibigtroth CM and Mitchell GS. Carotid chemoafferent activity is not necessary for all phrenic long-term facilitation following acute intermittent hypoxia. Respir Physiol Neurobiol. 2011. PMID 21093615.