Clinical Trials

Current Clinical Trials


Targeting Autophagy to Treat Glioma Across Species

NCI/NIH R01CA294557 PI: Yuanpei Li, Co-I: Toedebusch

Visit the Study Page

We are conducting a research study to learn more about a new experimental drug for dogs diagnosed with glioma, a type of brain tumor.

The main goals of this study are to:
  • Make sure the drug is safe for dogs
  • See whether the drug can reach brain tumors after being given through a vein
  • Learn whether the treatment may help dogs live longer

The experimental drug works by blocking a process that cancer cells use to protect themselves and survive. By stopping this process while dogs are also receiving radiation therapy, we hope to improve how well the tumor responds to treatment.


What does participation involve?

Dogs in the study will:

  • Have a brain tumor biopsy at the start of the study
  • Receive the experimental drug twice a week for four weeks
  • Receive standard radiation therapy at the same time
  • Have a brain tumor biopsy after treatment is complete

All dogs will be closely monitored by a veterinary neuro-oncology team throughout their participation.
 

Interested in Learning More?

If you would like more information or want to find out whether your dog may be eligible, please contact:
[email protected]

 

 

Longitudinal Characterization of Canine Glioma

Center for Companion Animal Health PI: Toedebusch

We are conducting a research study to better understand how glioma, a type of brain tumor indogs, changes over time. By following dogs throughout their care, we hope to learn more about how these tumors behave and affect dogs’ health and quality of life.
 
The main goals of this study are to:
  • Learn how changes in the tumor’s genes may affect how the disease progresses in dogs receiving comfort care (palliative care) how genetic mutations in the tumor affect the clinical progression of dogs receiving palliative care
  • Learn how these genetic changes may affect dogs receiving radiation therapy
  • Help identify new treatment options for dogs with glioma brain tumors in the future

What does participation involve?

Dogs in the study will:

  • Have a brain tumor biopsy at the start of the study
  • Receive monthly check-ups and brain MRI scans
  • May receive radiation, depending on the owner’s wishes

All dogs will be closely monitored by a veterinary neuro-oncology team throughout their participation.


Interested in Learning More?

If you would like more information or want to find out whether your dog may be eligible, please contact:
[email protected]